Accommodating chromosome inversions in linkage analysis.
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ABSTRACT:
SUBMITTER: Chen GK
PROVIDER: S-EPMC1559487 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Publications
Accommodating chromosome inversions in linkage analysis.
Chen Gary K GK Slaten Erin E Ophoff Roel A RA Lange Kenneth K
American journal of human genetics 20060606 2
This work develops a population-genetics model for polymorphic chromosome inversions. The model precisely describes how an inversion changes the nature of and approach to linkage equilibrium. The work also describes algorithms and software for allele-frequency estimation and linkage analysis in the presence of an inversion. The linkage algorithms implemented in the software package Mendel estimate recombination parameters and calculate the posterior probability that each pedigree member carries ...[more]
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