Ontology highlight
ABSTRACT:
SUBMITTER: Herold A
PROVIDER: S-EPMC155991 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Herold Andrea A Teixeira Luis L Izaurralde Elisa E
The EMBO journal 20030501 10
NXF1, p15 and UAP56 are essential nuclear mRNA export factors. The fraction of mRNAs exported by these proteins or via alternative pathways is unknown. We have analyzed the relative abundance of nearly half of the Drosophila transcriptome in the cytoplasm of cells treated with the CRM1 inhibitor leptomycin-B (LMB) or depleted of export factors by RNA interference. While the vast majority of mRNAs were unaffected by LMB, the levels of most mRNAs were significantly reduced in cells depleted of NXF ...[more]