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ABSTRACT:
SUBMITTER: Iqbalsyah TM
PROVIDER: S-EPMC1560106 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Iqbalsyah Teuku M TM Doig Andrew J AJ
Biochemistry 20050801 31
Salt bridges between oppositely charged side chains are well-known to stabilize protein structure, though their contributions vary considerably. Here we study Glu-Lys and Lys-Glu salt bridges, formed when the residues are spaced i, i + 4 surface of an isolated alpha-helix in aqueous solution. Both are stabilizing by -0.60 and -1.02 kcal/mol, respectively, when the interacting residues are fully charged. When the side chains are spaced i, i + 4, i + 8, forming a Glu-Lys-Glu triplet, the second sa ...[more]