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Integration of human immunodeficiency virus type 1 in untreated infection occurs preferentially within genes.


ABSTRACT: Previous analyses of human immunodeficiency virus type 1 (HIV-1) integration sites generated in infections in vitro or in patients in whom viral replication was repressed by antiviral therapy have demonstrated a preference for integration within protein-coding genes. We analyzed integration sites in peripheral blood mononuclear cells (PBMCs), spleen, lymph node, and cerebral cortex from patients with untreated HIV-1 infections. The great majority of integration sites in each tissue were within genes. Statistical analyses of the frequencies of integration in genes in PBMCs and lymph tissue demonstrated a strong preference for integration within genes. Although the sample size for brain tissue was too small to demonstrate a clear statistical preference for integration in genes, four of the five integration sites identified in brain were within genes. Taken together, our data indicate that HIV-1 preferentially integrates within genes during untreated infection.

SUBMITTER: Liu H 

PROVIDER: S-EPMC1563729 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature

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Integration of human immunodeficiency virus type 1 in untreated infection occurs preferentially within genes.

Liu Hongbing H   Dow Eugene C EC   Arora Reetakshi R   Kimata Jason T JT   Bull Lara M LM   Arduino Roberto C RC   Rice Andrew P AP  

Journal of virology 20060801 15


Previous analyses of human immunodeficiency virus type 1 (HIV-1) integration sites generated in infections in vitro or in patients in whom viral replication was repressed by antiviral therapy have demonstrated a preference for integration within protein-coding genes. We analyzed integration sites in peripheral blood mononuclear cells (PBMCs), spleen, lymph node, and cerebral cortex from patients with untreated HIV-1 infections. The great majority of integration sites in each tissue were within g  ...[more]

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