Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC1563729 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Liu Hongbing H Dow Eugene C EC Arora Reetakshi R Kimata Jason T JT Bull Lara M LM Arduino Roberto C RC Rice Andrew P AP
Journal of virology 20060801 15
Previous analyses of human immunodeficiency virus type 1 (HIV-1) integration sites generated in infections in vitro or in patients in whom viral replication was repressed by antiviral therapy have demonstrated a preference for integration within protein-coding genes. We analyzed integration sites in peripheral blood mononuclear cells (PBMCs), spleen, lymph node, and cerebral cortex from patients with untreated HIV-1 infections. The great majority of integration sites in each tissue were within g ...[more]