Ontology highlight
ABSTRACT:
SUBMITTER: Bell NM
PROVIDER: S-EPMC3928988 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Bell Neil M NM L'Hernault Anne A Murat Pierre P Richards James E JE Lever Andrew M L AM Balasubramanian Shankar S
Biochemistry 20131210 51
RNA-protein interactions are vital throughout the HIV-1 life cycle for the successful production of infectious virus particles. One such essential RNA-protein interaction occurs between the full-length genomic viral RNA and the major structural protein of the virus. The initial interaction is between the Gag polyprotein and the viral RNA packaging signal (psi or Ψ), a highly conserved RNA structural element within the 5'-UTR of the HIV-1 genome, which has gained attention as a potential therapeu ...[more]