Intra- and intersubtype alternative Pak2-activating structural motifs of human immunodeficiency virus type 1 Nef.
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ABSTRACT:
SUBMITTER: O'Neill E
PROVIDER: S-EPMC1563850 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Publications
Intra- and intersubtype alternative Pak2-activating structural motifs of human immunodeficiency virus type 1 Nef.
O'Neill Eduardo E Baugh Laura L LL Novitsky Vladimir A VA Essex Myron E ME Garcia J Victor JV
Journal of virology 20060901 17
The design of antiviral strategies against human immunodeficiency virus type 1 (HIV-1) has been largely derived from studies of subtype B viruses, although they constitute only 12% of infections worldwide. At 50% of all HIV-1 infections worldwide, subtype C viruses are the most predominant. Here, we present evidence that subtype C Nefs display functional Pak2-activating motifs that differ from those found in subtype B and E Nefs. The identification of multiple Pak2-activating structural motifs t ...[more]
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