Ontology highlight
ABSTRACT:
SUBMITTER: Itoh K
PROVIDER: S-EPMC1564280 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Itoh Kazuhito K Sasai Masaki M
Proceedings of the National Academy of Sciences of the United States of America 20060428 19
The folding pathway of the B domain of protein A is the pathway most intensively studied by computer simulations. Recent systematic measurement of Phi values by Sato et al., however, has shown that none of the published computational predictions is consistent with the detailed features of the experimentally observed folding mechanism. In this article we use a statistical mechanical model of folding to show that sensitive dependence of multiple transition state ensembles on temperature and the de ...[more]