Ontology highlight
ABSTRACT:
SUBMITTER: Myung SJ
PROVIDER: S-EPMC1567703 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Myung Seung-Jae SJ Rerko Ronald M RM Yan Min M Platzer Petra P Guda Kishore K Dotson Angela A Lawrence Earl E Dannenberg Andrew J AJ Lovgren Alysia Kern AK Luo Guangbin G Pretlow Theresa P TP Newman Robert A RA Willis Joseph J Dawson Dawn D Markowitz Sanford D SD
Proceedings of the National Academy of Sciences of the United States of America 20060731 32
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers. Herein, we demonstrate that 15-PGDH is active in vivo as a highly potent suppressor of colon neoplasia development and acts in the colon as a required physiologic antagonist of the prostaglandin-synthesizing activity of the cyclooxygenase 2 (COX-2) oncogene. We first show that 15-PGDH gene knockout induces a marked 7. ...[more]