Ontology highlight
ABSTRACT:
SUBMITTER: Yan M
PROVIDER: S-EPMC536023 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Yan Min M Rerko Ronald M RM Platzer Petra P Dawson Dawn D Willis Joseph J Tong Min M Lawrence Earl E Lutterbaugh James J Lu Shilong S Willson James K V JK Luo Guangbin G Hensold Jack J Tai Hsin-Hsiung HH Wilson Keith K Markowitz Sanford D SD
Proceedings of the National Academy of Sciences of the United States of America 20041201 50
Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic event in the genesis of human colon neoplasia. We report that, in addition to inducing expression of COX-2, colon cancers further target the prostaglandin biogenesis pathway by ubiquitously abrogating expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme tha ...[more]