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Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes.

ABSTRACT: Lymph node (LN) development depends on prenatal interactions occurring between LN inducer and LN organizer cells. We have distinguished defects in LN formation due to failure in embryonic development (aly/aly) from defects in postnatal maturation (Il2rgamma(-/-)Rag2(-/-)). Both mutant strains form normal primordial LNs with differing fate. In aly/aly mice, the LN primordium dissipates irreversibly late in gestation; in contrast, Il2rgamma(-/-)Rag2(-/-) LN anlage persists for a week after birth but disperses subsequently, a process reversible by neonatal transfer of WT IL7r(+) TCR(+) T or natural killer (NK) cells, suggesting a role for IL7/IL7r interactions. Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role.

SUBMITTER: Coles MC

PROVIDER: S-EPMC1569185 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature

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Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes.

Coles Mark C MC Veiga-Fernandes Henrique H Foster Katie E KE Norton Trisha T Pagakis Stamatis N SN Seddon Ben B Kioussis Dimitris D

Proceedings of the National Academy of Sciences of the United States of America 20060824 36

Lymph node (LN) development depends on prenatal interactions occurring between LN inducer and LN organizer cells. We have distinguished defects in LN formation due to failure in embryonic development (aly/aly) from defects in postnatal maturation (Il2rgamma(-/-)Rag2(-/-)). Both mutant strains form normal primordial LNs with differing fate. In aly/aly mice, the LN primordium dissipates irreversibly late in gestation; in contrast, Il2rgamma(-/-)Rag2(-/-) LN anlage persists for a week after birth b ...[more]

PMID: 16938836

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