Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC1569433 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Li Jun J Lee Wei-Lih WL Cooper John A JA
Nature cell biology 20050619 7
Dynein is a minus-end-directed microtubule motor with critical roles in mitosis, membrane transport and intracellular transport. Several proteins regulate dynein activity, including dynactin, LIS1 (refs 2, 3) and NudEL (NudE-like). Here, we identify a NUDEL homologue in budding yeast and name it Ndl1. The ndl1delta null mutant shows decreased targeting of dynein to microtubule plus ends, an essential element of the model for dynein function. We find that Ndl1 regulates dynein targeting through L ...[more]