Ontology highlight
ABSTRACT:
SUBMITTER: Tan R
PROVIDER: S-EPMC6082141 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Tan Ruensern R Foster Peter J PJ Needleman Daniel J DJ McKenney Richard J RJ
Developmental cell 20180101 2
Cytoplasmic dynein-1 is a minus-end-directed motor protein that transports cargo over long distances and organizes the intracellular microtubule (MT) network. How dynein motor activity is harnessed for these diverse functions remains unknown. Here, we have uncovered a mechanism for how processive dynein-dynactin complexes drive MT-MT sliding, reorganization, and focusing, activities required for mitotic spindle assembly. We find that motors cooperatively accumulate, in limited numbers, at MT min ...[more]