Scan of human genome reveals no new Loci under ancient balancing selection.
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ABSTRACT:
SUBMITTER: Bubb KL
PROVIDER: S-EPMC1569689 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
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Scan of human genome reveals no new Loci under ancient balancing selection.
Bubb K L KL Bovee D D Buckley D D Haugen E E Kibukawa M M Paddock M M Palmieri A A Subramanian S S Zhou Y Y Kaul R R Green P P Olson M V MV
Genetics 20060604 4
There has been much speculation as to what role balancing selection has played in evolution. In an attempt to identify regions, such as HLA, at which polymorphism has been maintained in the human population for millions of years, we scanned the human genome for regions of high SNP density. We found 16 regions that, outside of HLA and ABO, are the most highly polymorphic regions yet described; however, evidence for balancing selection at these sites is notably lacking--indeed, whole-genome simula ...[more]
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