Ontology highlight
ABSTRACT:
SUBMITTER: Akk G
PROVIDER: S-EPMC1571784 | biostudies-literature | 1999 Dec
REPOSITORIES: biostudies-literature
British journal of pharmacology 19991201 7
1. The dose-response parameters of recombinant mouse adult neuromuscular acetylcholine receptor channels (nAChR) activated by carbamylcholine, nicotine, muscarine and oxotremorine were measured. Rate constants for agonist association and dissociation, and channel opening and closing, were estimated from single-channel kinetic analysis. 2. The dissociation equilibrium constants were (mM): ACh (0. 16)<oxotremorine M (0.6)<carbamylcholine (0.8)<nicotine (2.6). 3. The gating equilibrium constants (o ...[more]