Ontology highlight
ABSTRACT:
SUBMITTER: Yang Q
PROVIDER: S-EPMC6580797 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Yang Qingyi Q Lachapelle Erik A EA Kablaoui Natasha M NM Webb Damien D Popiolek Michael M Grimwood Sarah S Kozak Rouba R O'Connor Rebecca E RE Lazzaro John T JT Butler Christopher R CR Zhang Lei L
ACS medicinal chemistry letters 20190528 6
It has been hypothesized that selective muscarinic acetylcholine receptor (mAChR) M4 subtype activation could provide therapeutic benefits to a number of neurological disorders while minimizing unwanted cholinergic side effects observed due to nonselective mAChR activation. Given the high sequence and structural homology of the orthosteric binding sites among mAChRs, achieving M4 subtype-selective activation has been challenging. Herein, we describe the discovery of a series of M4 subtype-select ...[more]