Association of SWAP-70 with the B cell antigen receptor complex.
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ABSTRACT:
SUBMITTER: Masat L
PROVIDER: S-EPMC15774 | biostudies-literature | 2000 Feb
REPOSITORIES: biostudies-literature
Publications
Association of SWAP-70 with the B cell antigen receptor complex.
Masat L L Caldwell J J Armstrong R R Khoshnevisan H H Jessberger R R Herndier B B Wabl M M Ferrick D D
Proceedings of the National Academy of Sciences of the United States of America 20000201 5
SWAP-70 is a component of an enzyme complex that recombines Ig switch regions in vitro. We report here the cloning of the human cDNA and its B lymphocyte-specific expression. Although its sequence contains three nuclear localization signals, in small resting B cells, SWAP-70 is mainly found in the cytoplasm. On stimulation, SWAP-70 translocates to the nucleus. In activated, class-switching B cell cultures, it is associated with membrane IgG, but not IgM. The membrane Ig association requires a fu ...[more]
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