Ontology highlight
ABSTRACT:
SUBMITTER: Gottwick C
PROVIDER: S-EPMC6613136 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Gottwick Cornelia C He Xiaocui X Hofmann Andreas A Vesper Niklas N Reth Michael M Yang Jianying J
Proceedings of the National Academy of Sciences of the United States of America 20190617 27
B lymphocytes have the ability to sense thousands of structurally different antigens and produce cognate antibodies against these molecules. For this they carry on their surface multiple copies of the B cell antigen receptor (BCR) comprising the membrane-bound Ig (mIg) molecule and the Igα/Igβ heterodimer functioning as antigen binding and signal transducing components, respectively. The mIg is a symmetric complex of 2 identical membrane-bound heavy chains (mHC) and 2 identical light chains. How ...[more]