Ontology highlight
ABSTRACT:
SUBMITTER: Rothenberg ME
PROVIDER: S-EPMC1595447 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Rothenberg Marc E ME Doepker Matthew P MP Lewkowich Ian P IP Chiaramonte Monica G MG Stringer Keith F KF Finkelman Fred D FD MacLeod Carol L CL Ellies Lesley G LG Zimmermann Nives N
Proceedings of the National Academy of Sciences of the United States of America 20060926 40
Arginine is an amino acid that serves as a substrate for nitric oxide synthase and arginase. As such, arginine has the potential to influence diverse fundamental processes in the lung. Here we report that the arginine transport protein, cationic amino acid transporter (CAT)2, has a critical role in regulating lung inflammatory responses. Analysis of CAT2-deficient mice revealed spontaneous inflammation in the lung. Marked eosinophilia, associated with up-regulation of eotaxin-1, was present in t ...[more]