Ontology highlight
ABSTRACT:
SUBMITTER: Jeung YJ
PROVIDER: S-EPMC6447956 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Jeung Yun-Ji YJ Lee Kyeong K Lee Hyo Jin HJ Kim Eunah E Son Myung Jin MJ Ahn Jiwon J Kim Han-Gyeul HG Kim Wantae W Lee Ho-Joon HJ Kim Jin Man JM Chung Kyung-Sook KS
Cancer science 20190319 4
Tumor cells overexpress amino acid transporters to meet the increased demand for amino acids. PQ loop repeat-containing (PQLC)2 is a cationic amino acid transporter that might be involved in cancer progression. Here, we show that upregulation of PQLC2 is critical to gastric cancer (GC) development in vitro and in vivo. Both PQLC2 mRNA and protein were overexpressed in GC tissues, especially of the diffuse type. Overexpression of PQLC2 promoted cell growth, anchorage independence, and tumor forma ...[more]