Hormonal activity of AIMP1/p43 for glucose homeostasis.
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ABSTRACT:
SUBMITTER: Park SG
PROVIDER: S-EPMC1595450 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Publications
Hormonal activity of AIMP1/p43 for glucose homeostasis.
Park Sang Gyu SG Kang Young Sun YS Kim Jin Young JY Lee Chang Seok CS Ko Young Gyu YG Lee Woo Je WJ Lee Ki-Up KU Yeom Young Il YI Kim Sunghoon S
Proceedings of the National Academy of Sciences of the United States of America 20060925 40
AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic alpha cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon- ...[more]
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