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Hormonal activity of AIMP1/p43 for glucose homeostasis.


ABSTRACT: AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic alpha cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.

SUBMITTER: Park SG 

PROVIDER: S-EPMC1595450 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature

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Hormonal activity of AIMP1/p43 for glucose homeostasis.

Park Sang Gyu SG   Kang Young Sun YS   Kim Jin Young JY   Lee Chang Seok CS   Ko Young Gyu YG   Lee Woo Je WJ   Lee Ki-Up KU   Yeom Young Il YI   Kim Sunghoon S  

Proceedings of the National Academy of Sciences of the United States of America 20060925 40


AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic alpha cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-  ...[more]

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