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Modes of regulation of RpoS by H-NS.


ABSTRACT: Regulated degradation of RpoS requires RssB and ClpXP protease. Mutations in hns increase both RpoS synthesis and stability, causing a twofold increase in synthesis and almost complete stabilization of RpoS, independent of effects on synthesis and independent of phosphorylation of RssB. This suggests that H-NS regulates an RssB inhibitor or inhibitors.

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC1595528 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature

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Modes of regulation of RpoS by H-NS.

Zhou YanNing Y   Gottesman Susan S  

Journal of bacteriology 20061001 19


Regulated degradation of RpoS requires RssB and ClpXP protease. Mutations in hns increase both RpoS synthesis and stability, causing a twofold increase in synthesis and almost complete stabilization of RpoS, independent of effects on synthesis and independent of phosphorylation of RssB. This suggests that H-NS regulates an RssB inhibitor or inhibitors. ...[more]

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