Ontology highlight
ABSTRACT:
SUBMITTER: Osajima-Hakomori Y
PROVIDER: S-EPMC1603453 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Osajima-Hakomori Yuko Y Miyake Izumi I Ohira Miki M Nakagawara Akira A Nakagawa Atsuko A Sakai Ryuichi R
The American journal of pathology 20050701 1
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor originally identified as part of the chimeric nucleophosmin-ALK protein in the t(2;5) chromosomal rearrangement associated with anaplastic large cell lymphoma. We recently demonstrated that the ALK kinase is constitutively activated by gene amplification at the ALK locus in several neuroblastoma cell lines. Forming a stable complex with hyperphosphorylated ShcC, activated ALK modifies the responsiveness of the mitogen-activated prote ...[more]