Ontology highlight
ABSTRACT:
SUBMITTER: Wardell B
PROVIDER: S-EPMC1617053 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Wardell Bryan B Marik Purba S PS Piper David D Rutar Tina T Jorgensen Erik M EM Bamber Bruce A BA
British journal of pharmacology 20060501 2
The GABA(A) receptor is a target of endogenous and synthetic neurosteroids. Little is known about the residues required for neurosteroid action on GABA(A) receptors. We have investigated pregnenolone sulfate (PS) inhibition of the Caenorhabditis elegans UNC-49 GABA receptor, a close homolog of the mammalian GABA(A) receptor. The UNC-49 locus encodes two GABA receptor subunits, UNC-49B and UNC-49C. UNC-49C is sensitive to PS but UNC-49B is not sensitive. By analyzing chimeric receptors and recept ...[more]