Ontology highlight
ABSTRACT:
SUBMITTER: Kirisako T
PROVIDER: S-EPMC1618115 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
The EMBO journal 20060928 20
The ubiquitin system plays important roles in the regulation of numerous cellular processes by conjugating ubiquitin to target proteins. In most cases, conjugation of polyubiquitin to target proteins regulates their function. In the polyubiquitin chains reported to date, ubiquitin monomers are linked via isopeptide bonds between an internal Lys and a C-terminal Gly. Here, we report that a protein complex consisting of two RING finger proteins, HOIL-1L and HOIP, exhibits ubiquitin polymerization ...[more]