Ontology highlight
ABSTRACT:
SUBMITTER: Dengg M
PROVIDER: S-EPMC1618380 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Dengg Marlene M Garcia-Muse Tatiana T Gill Stephen G SG Ashcroft Neville N Boulton Simon J SJ Nilsen Hilde H
EMBO reports 20060908 10
Incorporation of uracil during DNA synthesis is among the most common types of endogenously generated DNA damage. Depletion of Caenorhabditis elegans dUTPase by RNA interference allowed us to study the role of DNA damage response (DDR) pathways when responding to high levels of uracil in DNA. dUTPase depletion compromised development, caused embryonic lethality and led to activation of cell-cycle arrest and apoptosis. These phenotypes manifested as a result of processing misincorporated uracil b ...[more]