Ontology highlight
ABSTRACT:
SUBMITTER: Marsden CG
PROVIDER: S-EPMC5859333 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Marsden Carolyn G CG Dragon Julie A JA Wallace Susan S SS Sweasy Joann B JB
Methods in enzymology 20170505
Base excision repair (BER) is a key genome maintenance pathway that removes endogenously damaged DNA bases that arise in cells at very high levels on a daily basis. Failure to remove these damaged DNA bases leads to increased levels of mutagenesis and chromosomal instability, which have the potential to drive carcinogenesis. Next-generation sequencing of the germline and tumor genomes of thousands of individuals has uncovered many rare mutations in BER genes. Given that BER is critical for genom ...[more]