Ontology highlight
ABSTRACT:
SUBMITTER: Sun XF
PROVIDER: S-EPMC1618857 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Molecular cancer 20061006
Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, stromal variables within or around tumours, including blood and lymph vessels, stromal cells and various proteins, have also important impacts on tumour development and progression. It has been shown that disruption of stromal-epithelial interactions influences cellular proliferation, differ ...[more]