Ontology highlight
ABSTRACT:
SUBMITTER: Nardini M
PROVIDER: S-EPMC162135 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Nardini Marco M Spanò Stefania S Cericola Claudia C Pesce Alessandra A Massaro Anna A Millo Enrico E Luini Alberto A Corda Daniela D Bolognesi Martino M
The EMBO journal 20030601 12
C-terminal-binding protein/brefeldin A-ADP ribosylated substrate (CtBP/BARS) plays key roles in development and oncogenesis as a transcription co-repressor, and in intracellular traffic as a promoter of Golgi membrane fission. Co-repressor activity is regulated by NAD(H) binding to CtBP/BARS, while membrane fission is associated with its acyl-CoA-dependent acyltransferase activity. Here, we report the crystal structures of rat CtBP/BARS in a binary complex with NAD(H), and in a ternary complex w ...[more]