Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes.
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ABSTRACT:
SUBMITTER: Figueroa A
PROVIDER: S-EPMC162217 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
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Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes.
Figueroa Angélica A Cuadrado Ana A Fan Jinshui J Atasoy Ulus U Muscat George E GE Muñoz-Canoves Pura P Gorospe Myriam M Muñoz Alberto A
Molecular and cellular biology 20030701 14
In this report, we investigate the role of the RNA-binding protein HuR during skeletal myogenesis. At the onset of myogenesis in differentiating C2C12 myocytes and in vivo in regenerating mouse muscle, HuR cytoplasmic abundance increased dramatically, returning to a predominantly nuclear presence upon completion of myogenesis. mRNAs encoding key regulators of myogenesis-specific transcription (myogenin and MyoD) and cell cycle withdrawal (p21), bearing AU-rich regions, were found to be targets o ...[more]
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