Ontology highlight
ABSTRACT:
SUBMITTER: Broderick P
PROVIDER: S-EPMC1624846 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Broderick Peter P Bagratuni Tina T Vijayakrishnan Jairam J Lubbe Steven S Chandler Ian I Houlston Richard S RS
BMC cancer 20061009
<h4>Background</h4>The observation that germline mutations in the oxidative DNA damage repair gene MUTYH cause colorectal cancer (CRC) provides strong evidence that dysregulation of the base excision repair (BER) pathway influences disease susceptibility. It is conceivable that germline sequence variation in other BER pathway genes such as NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 also contribute to CRC susceptibility.<h4>Methods</h4>To evaluate whether sequence variants of NTHL1, NEIL1, NEIL ...[more]