Ontology highlight
ABSTRACT:
SUBMITTER: Varma R
PROVIDER: S-EPMC1626533 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Varma Rajat R Campi Gabriele G Yokosuka Tadashi T Saito Takashi T Dustin Michael L ML
Immunity 20060701 1
T cell receptor (TCR) signaling is initiated and sustained in microclusters; however, it's not known whether signaling also occurs in the TCR-rich central supramolecular activation cluster (cSMAC). We showed that the cSMAC formed by fusion of microclusters contained more CD45 than microclusters and is a site enriched in lysobisphosphatidic acid, a lipid involved in sorting ubiquitinated membrane proteins for degradation. Calcium signaling via TCR was blocked within 2 min by anti-MHCp treatment a ...[more]