Ontology highlight
ABSTRACT:
SUBMITTER: He H
PROVIDER: S-EPMC1630418 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
He Hua H Multani Asha S AS Cosme-Blanco Wilfredo W Tahara Hidetoshi H Ma Jin J Pathak Sen S Deng Yibin Y Chang Sandy S
The EMBO journal 20061019 21
POT1 (protection of telomere 1) is a highly conserved single-stranded telomeric binding protein that is essential for telomere end protection. Here, we report the cloning and characterization of a second member of the mouse POT family. POT1b binds telomeric DNA via conserved DNA binding oligonucleotide/oligosaccharide (OB) folds. Compared to POT1a, POT1b OB-folds possess less sequence specificity for telomeres. In contrast to POT1a, truncated POT1b possessing only the OB-folds can efficiently lo ...[more]