Ontology highlight
ABSTRACT:
SUBMITTER: Rai R
PROVIDER: S-EPMC4785230 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Rai Rekha R Chen Yong Y Lei Ming M Chang Sandy S
Nature communications 20160304
Repressor/activator protein 1 (RAP1) is a highly conserved telomere-interacting protein. Yeast Rap1 protects telomeres from non-homologous end joining (NHEJ), plays important roles in telomere length control and is involved in transcriptional gene regulation. However, a role for mammalian RAP1 in telomere end protection remains controversial. Here we present evidence that mammalian RAP1 is essential to protect telomere from homology directed repair (HDR) of telomeres. RAP1 cooperates with the ba ...[more]