Ontology highlight
ABSTRACT:
SUBMITTER: Brown DD
PROVIDER: S-EPMC1635804 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20050105 3
Members of the T-box family of proteins play a fundamental role in patterning the developing vertebrate heart; however, the precise cellular requirements for any one family member and the mechanism by which individual T-box genes function remains largely unknown. In this study, we have investigated the cellular and molecular relationship between two T-box genes, Tbx5 and Tbx20. We demonstrate that blocking Tbx5 or Tbx20 produces phenotypes that display a high degree of similarity, as judged by o ...[more]