Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez PP
PROVIDER: S-EPMC4589158 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Hernández Pedro P PP Mahlakoiv Tanel T Yang Ines I Schwierzeck Vera V Nguyen Nam N Guendel Fabian F Gronke Konrad K Ryffel Bernhard B Hoelscher Christoph C Dumoutier Laure L Renauld Jean-Christophe JC Suerbaum Sebastian S Staeheli Peter P Diefenbach Andreas A
Nature immunology 20150525 7
The epithelium is the main entry point for many viruses, but the processes that protect barrier surfaces against viral infections are incompletely understood. Here we identified interleukin 22 (IL-22) produced by innate lymphoid cell group 3 (ILC3) as an amplifier of signaling via interferon-λ (IFN-λ), a synergism needed to curtail the replication of rotavirus, the leading cause of childhood gastroenteritis. Cooperation between the receptor for IL-22 and the receptor for IFN-λ, both of which wer ...[more]