Ontology highlight
ABSTRACT:
SUBMITTER: Yeom KH
PROVIDER: S-EPMC1636349 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Yeom Kyu-Hyeon KH Lee Yoontae Y Han Jinju J Suh Mi Ra MR Kim V Narry VN
Nucleic acids research 20060908 16
DGCR8/Pasha is an essential cofactor for Drosha, a nuclear RNase III that cleaves the local hairpin structures embedded in long primary microRNA transcripts (pri-miRNAs) in eukaryotes. Although our knowledge of pri-miRNA processing has significantly advanced in recent years, the precise role of DGCR8 in this pathway remains unclear. In our present study, we dissect the domains in DGCR8 that contribute to the processing of pri-miRNAs and the subcellular localization of DGCR8. Drosha is stabilized ...[more]