Ontology highlight
ABSTRACT:
SUBMITTER: Han J
PROVIDER: S-EPMC2680683 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Han Jinju J Pedersen Jakob S JS Kwon S Chul SC Belair Cassandra D CD Kim Young-Kook YK Yeom Kyu-Hyeon KH Yang Woo-Young WY Haussler David D Blelloch Robert R Kim V Narry VN
Cell 20090101 1
The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate. Although the action mechanism of this complex has been intensively studied, it remains unclear how Drosha and DGCR8 are regulated and if these proteins have any additional role(s) apart from miRNA processing. Here, we report that Drosha and DGCR8 regulate each other posttranscriptionally. T ...[more]