Ontology highlight
ABSTRACT:
SUBMITTER: Muh U
PROVIDER: S-EPMC1636559 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Müh Ute U Hare Brian J BJ Duerkop Breck A BA Schuster Martin M Hanzelka Brian L BL Heim Roger R Olson Eric R ER Greenberg E Peter EP
Proceedings of the National Academy of Sciences of the United States of America 20061030 45
The pathogenic bacterium Pseudomonas aeruginosa uses acyl-homoserine lactone quorum-sensing signals to coordinate the expression of a battery of virulence genes in a cascade of regulatory events. The quorum-sensing signal that triggers the cascade is N-3-oxo-dodecanoyl homoserine lactone (3OC12-HSL), which interacts with two signal receptor-transcription factors, LasR and QscR. This signal is base labile, and it is degraded by mammalian PON lactonases. We have identified a structurally unrelated ...[more]