Ontology highlight
ABSTRACT:
SUBMITTER: Dodge-Kafka KL
PROVIDER: S-EPMC1636584 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Dodge-Kafka Kimberly L KL Soughayer Joseph J Pare Genevieve C GC Carlisle Michel Jennifer J JJ Langeberg Lorene K LK Kapiloff Michael S MS Scott John D JD
Nature 20050901 7058
Cyclic adenosine 3', 5'-monophosphate (cAMP) is a ubiquitous mediator of intracellular signalling events. It acts principally through stimulation of cAMP-dependent protein kinases (PKAs) but also activates certain ion channels and guanine nucleotide exchange factors (Epacs). Metabolism of cAMP is catalysed by phosphodiesterases (PDEs). Here we identify a cAMP-responsive signalling complex maintained by the muscle-specific A-kinase anchoring protein (mAKAP) that includes PKA, PDE4D3 and Epac1. Th ...[more]