Ontology highlight
ABSTRACT:
SUBMITTER: Yoshimaru T
PROVIDER: S-EPMC5512694 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Nature communications 20170530
Approximately 70% of breast cancer cells express oestrogen receptor alpha (ERα). Previous studies have shown that the Brefeldin A-inhibited guanine nucleotide-exchange protein 3-prohibitin 2 (BIG3-PHB2) complex has a crucial role in these cells. However, it remains unclear how BIG3 regulates the suppressive activity of PHB2. Here we demonstrate that BIG3 functions as an A-kinase anchoring protein that binds protein kinase A (PKA) and the α isoform of the catalytic subunit of protein phosphatase ...[more]