Ontology highlight
ABSTRACT:
SUBMITTER: Mai M
PROVIDER: S-EPMC1637098 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Mai Maren M Akkad Amer D AD Wieczorek Stefan S Saft Carsten C Andrich Jürgen J Kraus Peter H PH Epplen Jörg T JT Arning Larissa L
BMC medical genetics 20061110
<h4>Background</h4>Recent evidence suggests that brain-derived neurotrophic factor (BDNF) is an attractive candidate for modifying age at onset (AO) in Huntington disease (HD). In particular, the functional Val66Met polymorphism appeared to exert a significant effect. Here we evaluate BDNF variability with respect to AO of HD using markers that represent the entire locus.<h4>Methods</h4>Five selected tagging polymorphisms were genotyped across a 65 kb region comprising the BDNF gene in a well es ...[more]