Ontology highlight
ABSTRACT:
SUBMITTER: Djousse L
PROVIDER: S-EPMC1866166 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Djoussé Luc L Knowlton Beth B Hayden Michael R MR Almqvist Elisabeth W EW Brinkman Ryan R RR Ross Christopher A CA Margolis Russel L RL Rosenblatt Adam A Durr Alexandra A Dode Catherine C Morrison Patrick J PJ Novelletto Andrea A Frontali Marina M Trent Ronald J A RJ McCusker Elizabeth E Gómez-Tortosa Estrella E Mayo Cabrero David D Jones Randi R Zanko Andrea A Nance Martha M Abramson Ruth K RK Suchowersky Oksana O Paulsen Jane S JS Harrison Madaline B MB Yang Qiong Q Cupples L Adrienne LA Mysore Jayalakshmi J Gusella James F JF MacDonald Marcy E ME Myers Richard H RH
Neurogenetics 20040317 2
Huntington disease (HD) is a neurodegenerative disorder caused by the abnormal expansion of CAG repeats in the HD gene on chromosome 4p16.3. A recent genome scan for genetic modifiers of age at onset of motor symptoms (AO) in HD suggests that one modifier may reside in the region close to the HD gene itself. We used data from 535 HD participants of the New England Huntington cohort and the HD MAPS cohort to assess whether AO was influenced by any of the three markers in the 4p16 region: MSX1 (Dr ...[more]