Modeling CTLA4-linked autoimmunity with RNA interference in mice.
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ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC1637594 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Publications
Modeling CTLA4-linked autoimmunity with RNA interference in mice.
Chen Zhibin Z Stockton John J Mathis Diane D Benoist Christophe C
Proceedings of the National Academy of Sciences of the United States of America 20061023 44
The CTLA4 gene is important for T lymphocyte-mediated immunoregulation and has been associated with several autoimmune diseases, in particular, type 1 diabetes. To model the impact of natural genetic variants of CTLA4, we constructed RNA interference (RNAi) "knockdown" mice through lentiviral transgenesis. Variegation of expression was observed in founders but proved surmountable because it reflected parental imprinting, with derepression by transmission from male lentigenics. Unlike the indiscr ...[more]
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