Ontology highlight
ABSTRACT:
SUBMITTER: Kanai R
PROVIDER: S-EPMC1642136 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Kanai Ryuta R Kar Kalipada K Anthony Karen K Gould L Hannah LH Ledizet Michel M Fikrig Erol E Marasco Wayne A WA Koski Raymond A RA Modis Yorgo Y
Journal of virology 20060830 22
West Nile virus, a member of the Flavivirus genus, causes fever that can progress to life-threatening encephalitis. The major envelope glycoprotein, E, of these viruses mediates viral attachment and entry by membrane fusion. We have determined the crystal structure of a soluble fragment of West Nile virus E. The structure adopts the same overall fold as that of the E proteins from dengue and tick-borne encephalitis viruses. The conformation of domain II is different from that in other prefusion ...[more]