Ontology highlight
ABSTRACT:
SUBMITTER: Correia T
PROVIDER: S-EPMC164459 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Correia Trudy T Papayannopoulos Venizelos V Panin Vladislav V Woronoff Pamela P Jiang Jin J Vogt Thomas F TF Irvine Kenneth D KD
Proceedings of the National Academy of Sciences of the United States of America 20030512 11
Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modulate signaling through Notch receptors by modifying O-linked fucose on epidermal growth factor domains. Fringe is highly conserved, and comparison among 18 different Fringe proteins from 11 different species identifies a core set of 84 amino acids that are identical among all Fringes. Fringe is only distantly related to other glycosyltransferases, but analysis of the predicted Drosophila proteome identifies a set of four seque ...[more]