Increased localization precision by interference fringe analysis.

ABSTRACT: We report a novel optical single-emitter-localization methodology that uses the phase induced by path length differences in a Mach-Zehnder interferometer to improve localization precision. Using information theory, we demonstrate that the localization capability of a modified Fourier domain signal generated by photon interference enables a more precise localization compared to a standard Gaussian intensity distribution of the corresponding point-spread function. The calculations were verified by numerical simulations and an exemplary experiment, where the centers of metal nanoparticles were localized to a precision of 3 nm.

SUBMITTER: Ebeling CG 

PROVIDER: S-EPMC4827330 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature