Ontology highlight
ABSTRACT:
SUBMITTER: Sowa G
PROVIDER: S-EPMC164477 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Sowa Grzegorz G Pypaert Marc M Fulton David D Sessa William C WC
Proceedings of the National Academy of Sciences of the United States of America 20030512 11
Caveolin-1 and -2 are the two major coat proteins found in plasma membrane caveolae of most of cell types. Here, by using adenoviral transduction of either caveolin-1 or caveolin-2 or both isoforms into cells lacking both caveolins, we demonstrate that caveolin-2 positively regulates caveolin-1-dependent caveolae formation. More importantly, we show that caveolin-2 is phosphorylated in vivo at two serine residues and that the phosphorylation of caveolin-2 is necessary for its actions as a positi ...[more]