Unknown

Dataset Information

0

Structure-based reassessment of the caveolin signaling model: do caveolae regulate signaling through caveolin-protein interactions?


ABSTRACT: Caveolin proteins drive formation of caveolae, specialized cell-surface microdomains that influence cell signaling. Signaling proteins are proposed to use conserved caveolin-binding motifs (CBMs) to associate with caveolae via the caveolin scaffolding domain (CSD). However, structural and bioinformatic analyses argue against such direct physical interactions: in the majority of signaling proteins, the CBM is buried and inaccessible. Putative CBMs do not form a common structure for caveolin recognition, are not enriched among caveolin-binding proteins, and are even more common in yeast, which lack caveolae. We propose that CBM/CSD-dependent interactions are unlikely to mediate caveolar signaling, and the basis for signaling effects should therefore be reassessed.

SUBMITTER: Collins BM 

PROVIDER: S-EPMC3427029 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Structure-based reassessment of the caveolin signaling model: do caveolae regulate signaling through caveolin-protein interactions?

Collins Brett M BM   Davis Melissa J MJ   Hancock John F JF   Parton Robert G RG  

Developmental cell 20120701 1


Caveolin proteins drive formation of caveolae, specialized cell-surface microdomains that influence cell signaling. Signaling proteins are proposed to use conserved caveolin-binding motifs (CBMs) to associate with caveolae via the caveolin scaffolding domain (CSD). However, structural and bioinformatic analyses argue against such direct physical interactions: in the majority of signaling proteins, the CBM is buried and inaccessible. Putative CBMs do not form a common structure for caveolin recog  ...[more]

Similar Datasets

| S-EPMC4238006 | biostudies-literature
| S-EPMC2683698 | biostudies-literature
| S-EPMC206992 | biostudies-literature
| S-EPMC3248968 | biostudies-literature
| S-EPMC5417097 | biostudies-literature
| S-EPMC3072606 | biostudies-literature
| S-EPMC164477 | biostudies-literature
| S-EPMC6488599 | biostudies-literature
| S-EPMC5167190 | biostudies-literature
| S-EPMC4758735 | biostudies-literature