Ontology highlight
ABSTRACT:
SUBMITTER: Collins BM
PROVIDER: S-EPMC3427029 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Collins Brett M BM Davis Melissa J MJ Hancock John F JF Parton Robert G RG
Developmental cell 20120701 1
Caveolin proteins drive formation of caveolae, specialized cell-surface microdomains that influence cell signaling. Signaling proteins are proposed to use conserved caveolin-binding motifs (CBMs) to associate with caveolae via the caveolin scaffolding domain (CSD). However, structural and bioinformatic analyses argue against such direct physical interactions: in the majority of signaling proteins, the CBM is buried and inaccessible. Putative CBMs do not form a common structure for caveolin recog ...[more]