Ontology highlight
ABSTRACT:
SUBMITTER: Ghaffari S
PROVIDER: S-EPMC164479 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Ghaffari Saghi S Jagani Zainab Z Kitidis Claire C Lodish Harvey F HF Khosravi-Far Roya R
Proceedings of the National Academy of Sciences of the United States of America 20030515 11
Cytokine-provided survival signals are known to suppress apoptosis through inhibition of mitochondrial pathways that involve Bcl-2 family members. Here we show that in hematopoietic cells, cytokines also regulate death receptor-mediated pathways. We demonstrate that hematopoietic cytokines such as IL-3 and erythropoietin in normal cells, as well as BCR-ABL oncoprotein in transformed cells, inhibit transcription of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Using small inter ...[more]