Coexistence of two distinct secretion mutations (P5T and I97L) in hepatitis B virus core produces a wild-type pattern of secretion.
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ABSTRACT:
SUBMITTER: Chua PK
PROVIDER: S-EPMC164791 | biostudies-literature | 2003 Jul
REPOSITORIES: biostudies-literature
Publications
Coexistence of two distinct secretion mutations (P5T and I97L) in hepatitis B virus core produces a wild-type pattern of secretion.
Chua Pong Kian PK Wen Yu-Mei YM Shih Chiaho C
Journal of virology 20030701 13
Unlike a Tokyo isolate of hepatitis B virus variants, we found a Shanghai isolate that secretes few virions with an immature genome despite its core I97L mutation. Core mutations P5T and I97L were found to be mutually compensatory in offsetting their respective distinct effects on virion secretion. ...[more]
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